Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin. doi: 10.1002/ccr3.6096. The https:// ensures that you are connecting to the J Am Acad Dermatol. Dermoscopy showed dotted and linear vessels forming a network on a yellowish background, with some whitish peripheral scales (Figure 3A). A spectrum of cutaneous reactions to SARs-CoV-2 (COVID-19) vaccines have been reported in the literature. doi: 10.1111/ajd.13504. 2022 Feb 3;9 (2):003164. doi: 10.12890/2022_003164. All rights reserved. J Eur Acad Dermatol Venereol. Develop a large patch on your skin. We present two cases of COVID-19 vaccine-induced pityriasis rosea. PMC Before J Am Acad Dermatol. KL drafted the original manuscript. The typical distribution of the rash is on the trunk between the neck and the knees.". 2023 Feb 9;11(2):397. doi: 10.3390/vaccines11020397. doi: 10.1111/ijd.15700, 4. Keywords: Influenza viruses and vaccines have triggered pityriasis rosea in some cases.". Please enable it to take advantage of the complete set of features! doi: 10.1159/000517971. HHS Vulnerability Disclosure, Help PMC The .gov means its official. -, Polack FP, Thomas SJ, Kitchin N et al. 2022 Aug;87(2):295. doi: 10.1016/j.jaad.2022.06.036. In addition to COVID-19 vaccination, she was currently taking medications (i.e., levetiracetam and thyroxin) for glioblastoma, and the two drugs had been prescribed for approximately nine months. and transmitted securely. Cureus. The https:// ensures that you are connecting to the JAAD Case Rep. 2021;7:9394. An official website of the United States government. Pityriasis rosea after Moderna mRNA-1273 vaccine: A case series Rationale: Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same . Unauthorized use of these marks is strictly prohibited. (d) Patient 2: Closeup of plaques, with the hyperpigmented centre and trailing scale. The .gov means its official. J Am Acad Dermatol. PR also tends to occur in patients between the ages of 10 to 35 that are usually otherwise healthy, Lam says. PR is a common self-limited papulosquamous eruption typically presenting with a large solitary pink-colored patch or plaque (i.e., herald patch), followed by secondary eruptions of smaller erythematous patches or plaques with associated peripheral collarette scaling distributed along the cleavage lines of the trunk, forming a Christmas tree pattern (5). Luckily, it's not contagious. 2021;35(8):e489e491. Atzori L, Pinna AL, Ferreli C, Aste N. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center. Clipboard, Search History, and several other advanced features are temporarily unavailable. In: Knoop KJ, Stack LB, Storrow AB, et al., eds. Epub 2021 May 10. HHS Vulnerability Disclosure, Help Other plausible theories include molecular mimicry with viral epitopes and type IV delayed hypersensitivity reaction (12). Atypical pityriasis rosea associated with mRNA COVID19 vaccine E. Bostan, Adam Jarbou Published 29 September 2021 Medicine Journal of Medical Virology Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of Covid-19. I put on some hydrocortisone and went to sleep, then woke up with another mark on my side, a couple inches below my armpit. Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. While home remedies are safe for most people, its a good idea to check with your healthcare provider before trying some of the following options. However, after 14 days, she developed multiple discrete blanching erythematous oval patches and plaques on the lower abdomen, back, and bilateral upper thighs (Figures 1A,B). Marcantonio-Santa Cruz OY, Vidal-Navarro A, Pesqu D, Gimnez-Arnau AM, Pujol RM, Martin-Ezquerra G. J Eur Acad Dermatol Venereol. Ramot Y, Nanova K, Faitatziadou SM, Assab DA, Berkun Y, Zlotogorski A. J Dtsch Dermatol Ges. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. This Month in JAAD International: August 2022: Cutaneous reactions to COVID-19 messenger RNA booster dose vaccination. Hum Vaccin Immunother. 2022 Jul 8;101(27):e29823. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. Cutis. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. You cant spread pityriasis rosea to another person through unprotected sex or skin-to-skin contact. 2021 Nov 2;17(11):4097-4098. doi: 10.1080/21645515.2021.1963173. Due to the rising incidence of coronavirus disease 2019 (COVID-19) worldwide, mass vaccination has been the cornerstone in preventing viral spread and decreasing morbidity and mortality. I also had to stop working out and hiking for about a week, as Alexiades is right excessive perspiration worsened the itch. doi: 10.1016/j.jaad.2021.03.092, 15. Flares of other types of skin conditions [like psoriasis] sometimes have been described as well," says Lam. "Any type of stress on the body can sometimes [cause them, and] any vaccine, not just the COVID one.". While unusual, one patient developed pityriasis rosea once a year for five years in a row. eCollection 2022. However, several adverse effects of COVID-19 vaccination have been identified. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The patient had a positive RT-PCR result, and was confirmed with SARS-CoV-2 infection. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Unable to load your collection due to an error, Unable to load your delegates due to an error. They were found on hands and feet, showing up as red or purple spots caused by bleeding under the skin. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. Our experience with 80 cases of SARS-CoV-2-Clostridioides difficile co-infection: An observational study. You may develop a raised, discolored, circular or oval-shaped patch that ranges from 1 to 6 centimeters (cm). The rash itself usually doesnt blister or bleed, but in many cases, the skin may peel. Federal government websites often end in .gov or .mil. Br J Dermatol 2020; 183: 431442. Ad Choices. Pityriasis rosea as a cutaneous manifestation of COVID19 infection -, Recalcati S. Cutaneous manifestations in COVID-19: a first perspective. . Dermatol Reports. official website and that any information you provide is encrypted Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases. Int J Dermatol. 8 PDF Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases D. McMahon, E. Amerson, +11 authors E. Freeman Medicine Its important to pay attention to your skin. eCollection 2022 Jul. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine J Eur Acad Dermatol Venereol. (a) Patient 1: Thin, Histopathological findings of pityriasis rosealike, Histopathological findings of pityriasis rosealike eruption in patient 1. The good news is many of those who develop pityriasis rosea never get it again, says New York City-based dermatologist Hadley King. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Epub 2021 Apr 26. Got an extremely itchy rash that came seemingly out of nowhere? Most people with the rash are 10 to 35 years of age. Pityriasis rosea: Signs and symptoms - American Academy of Dermatology For most people, it resolves without treatment. -, Neoh CY, Tan AW, Mohamed K, et al. Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. "In studies, between 2 and 3 percent of people develop the disease again. What at-home treatments do you recommend? J Formos Med Assoc. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291919/). However, a fungus causes ringworm. Unable to load your collection due to an error, Unable to load your delegates due to an error. Pityriasis Rosea as a Possible Complication of Vaccination Against COVID-19. 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. How long will it take my body to clear the rash? Numerous scattered erythematous, Pityriasis rosea. This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. Lasers Med Sci. If you have pityriasis rosea, the rash with go away without treatment. Before Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. Physical examination revealed that lesions were distributed along cleavage lines, similar to PR, without herald patch or prominent scales (Figure 1C). Accessibility Epub 2022 Jan 31. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A Human herpesvirus-6,7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. The .gov means its official. HHS Vulnerability Disclosure, Help The available COVID-19 vaccines entail different levels of risk for skin reactions. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. (A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20). Clinical findings of pityriasis rosealike eruption in the patients. JAAD Int. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. If you develop pityriasis rosea, you may experience the following in this order: Feel ill for 1 or 2 days. Epub 2022 Jun 26. These findings were consistent with a diagnosis of PR-like eruption. In conclusion, we have described the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. This site needs JavaScript to work properly. Pityriasis rosea (pih-tuh-RY-uh-sis ROH-zee-uh) is a common skin condition that causes patches of your skin to develop raised, scaly rashes. J Invest Dermatol. Br J Dermatol. and transmitted securely. Some treatments can alleviate related symptoms, including itching. doi: 10.1111/jdv.17316. Diagnoses: According to King, an in-person skin exam is usually enough to make an accurate diagnosis, though a biopsy or blood work may be necessary for some. Do the medications have any side effects? Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. 2021 Sep;35(9):e546-e548. Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine Pityriasis rosea (PR) is an acute papulosquamous cutaneous disorder that classically presents with a herald patch rapidly followed by a widespread rash along skin cleavage lines. FOIA Kroumpouzos G, Paroikaki ME, Yumeen S, Bhargava S, Mylonakis E. Microorganisms. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. Abdullah L, Hasbani D, Kurban M, Abbas O. Pityriasis rosea after mRNA COVID-19 vaccination. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. doi: 10.1016/j.jaad.2020.04.094, 8. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. At first, I thought it could be a fungal infection like ringworm, a common misdiagnosis, says Hartman, but my dermatologist ruled that out when I mentioned the additional spots erupting on my back via our video chat. Treatment with topical 0.1% triamcinolone acetonide twice daily showed partial response after seven days. In a registry-based study, PR-like eruption was observed in only 12% of patients (14). doi: 10.1111/bjd.20143. Blood tests to check for causes of a rash that arent related to pityriasis rosea. For most people, it resolves without treatment. "And it has a particular [dermatomal] distribution because it's along a nerve," which also presents as fluid-filled blisters, rather than lesions. -, Drago F, Ciccarese G, Javor S, Parodi A. Vaccineinduced pityriasis rosea and pityriasis rosealike eruptions: a review of the literature. When to test for COVID-19 using real-time reverse transcriptase polymerase chain reaction: a systematic review. Pityriasis rosea-like Covid-arm Erythema multiforme Erythroderma Psoriasis Others Grover-like eruptions Herpes simplex reactivation: 24 1 17 4 2 2 1 1 20 15 9 5 2 1 1 1 3 3: 21.5 0.9 15 3.5 1.8 1.8 0.9 0.9 Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. (2020) 33:e13878. "It's usually not from head to toe that's more atypical but there are some people that get it more in the groin area or in the armpit rather than on the trunk predominantly, which is just a variant.". Allure may earn a portion of sales from products that are purchased through our site as part of our Affiliate Partnerships with Epub 2020 Jun 29. The ones found in people with pityriasis rosea are human herpesviruses 6 and 7. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. doi: 10.12998/wjcc.v5.i6.203, 6. Medicine (Baltimore). 2021;85(1):4655. 2022 Sep-Oct;40(5):586-590. doi: 10.1016/j.clindermatol.2022.01.002. Br J Dermatol. The most commonly inoculated vaccines include those against smallpox, followed by tuberculosis, poliomyelitis, influenza, and human papillomavirus virus (12, 13). KL and KP collated resources. Disclaimer. The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s. COVID-19-associated pityriasis rosea in children: Case report and literature review. The https:// ensures that you are connecting to the 8600 Rockville Pike Treatment was initiated with systemic corticosteroid therapy - hydrocortisone hemisuccinate 200 mg/day for 7 days, and loratadine 10 mg 2 times a day. American Academy of Dermatology's National Library of Dermatologic Teaching Slides. doi: 10.1111/dth.13730. Dermatol Ther. This site needs JavaScript to work properly. How quickly did it come on, and did my boyfriend also have it? New York City-based dermatologist Macrene Alexiades. This site needs JavaScript to work properly. Appointments 216.444.5725 Appointments & Locations Request an Appointment Get useful, helpful and relevant health + wellness information. Another skin condition identified in the study were "vesicular eruptions" seen in 9 per cent of cases. Indian J Dermatol 2016;61:37584. Suchonwanit P, Rojhirunsakool S, Khunkhet S. A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. It should clear your body in six to eight weeks. An official website of the United States government. Pityriasis rosea-like rash after messenger RNA COVID-19 - PubMed Federal government websites often end in .gov or .mil. How do dermatologists treat pityriasis rosea? Shabazz DR. Pityriasis Rosea. doi: 10.1111/jdv.12942, 13. Your Random Rash Could Be Pityriasis Rosea | Allure 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Bethesda, MD 20894, Web Policies Zendaya Shows Off Her Short Sunshine Curls. If you have a very itchy rash, your healthcare provider may prescribe the following to help relieve your symptoms: There are several over-the-counter products or home remedies that can help stop your rash from itching. The average time between vaccination and rash onset is 10 days, and most patients experience pruritus (70%). 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. A team of researchers . Epub 2021 Aug 7. Your California Privacy Rights. Interventions: Oily fish, such as mackerel, salmon or sardines. Disseminated erythematous-papulosquamous lesions, with right laterocervical herald patch (clinical aspect on admission). National Library of Medicine Shingles was another fear, as I had chicken pox when I was four, but we ruled that out too: "Shingles is a nerve-mediated process; it tends to be very painful, not so itchy," Lam says. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753512/), Visitation, mask requirements and COVID-19 information, sexually transmitted disease or infection. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. The exanthem was self-limited in both patients over a period of a month. Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report. doi: 10.1097/MD.0000000000029823. However, there isnt enough research to determine that stress may cause pityriasis rosea. One week before the rash, respiratory tract infection symptomatology was observed by the patient. They develop in a pattern that resembles sagging Christmas tree branches. Drago F, Ciccarese G, Javor S, et al. JAAD Case Rep 2018; 4: 800801. If I dont have pityriasis rosea, what other skin condition might I have? The patient presented to the Department of Dermatology for a 3 week duration of an extremely pruritic erythematous-squamous lesion, initially on the trunk and upper limbs, with extension to the lower limbs in the last week and the lesion respected the cephalic extremity, palms, and soles. Herzum A, Trave I, D'Agostino F, Burlando M, Cozzani E, Parodi A. Clin Exp Vaccine Res. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. This reaction is self-limited and resolves in an average of 5.6 weeks. A woman. Suchonwanit P, Triamchaisri S, Wittayakornrerk S, Rattanakaemakorn P. Leprosy Reaction in Thai Population: A 20-Year Retrospective Study. Unauthorized use of these marks is strictly prohibited. Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. Dermatology. National Library of Medicine government site. Epub 2022 Jun 14. retailers. Disclaimer. 2020 Jul;33(4):e13730. Studies show that the development of pityriasis rosea during pregnancy may cause birth complications, including miscarriage and poor muscle tone and development once the baby is born (neonatal hypotonia). The study said the appearance was similar to pityriasis rosea, a common skin condition. The papulovesicular and pityriasis rosea . Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review. Adya KA, Inamadar AC, Albadri W. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. J Am Acad Dermatol. Although the exact pathophysiologic mechanisms of PR after vaccination remain unclear, immune responses to COVID-19 vaccines and disruption of T-cell mediated control of latent infections were implicated (12, 1518). (2021) 35:e4913. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature.
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