Rev. The design was prospective, open-labeled, variable doses in volunteers. Ayurvedic pharmacodynamics of C. longa are described as follows: Rasa - tikta and katu, Guna - rukhsha and laghu, Virya - ushna, Vipak - katu and Doshaghnata - tridoshshamak. Drug discovery, at the bedside, is followed in reverse pharmacology (RP) by the relevant science of drug development for safety, efficacy, and m... Aryavaidya Mayaram Sundarji (1856-1928) was a visionary who took early initiatives for Ayurvidya- integrative approaches to incorporate modern scientific advances in Ayurveda. He is widely known for his research in Ayurveda and interest in what he calls reverse pharmacology. in human urine. Dr. Vaidya has more than 290 research publications to his credit. The first mention that I could find by Vaidya of reverse pharmacology PMID 18392106 was in 2007. Dr Ashok Vaidya moved to Yale with the Merck International Fellowship and then joined the CIBA Research Centre, Mumbai. leaves, Effect of drying methods on the antioxidant activity of Anacardium occidentale L. (Cashew), Reactive oxygen species, anti-oxidant enzymes and smoldering chronic infammation: Relevance to diabetes mellitus, atherosclerosis, and menopausal metabolic syndrome, Genoprotective Effect of Indian Gentian in Type 2 Diabetes Mellitus (T2DM): Comet Assay, Sister Chromatid Exchange and Protein Oxidation Studies, Growth inhibition of struvite crystals by the aqueous root extract of Rotula aquatica, Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction, Yellow nail syndrome: Missed diagnosis of a rare syndrome, Vaidya-Scientists: Catalysing Ayurveda Renaissance, Chemopreventive Potential and Safety Profile of a Curcuma longa Extract in Women with Cervical Low-Grade Squamous Intraepithelial Neoplasia, Antioxidant activity of various extracts of leaves of anacardium occidentale (Cashew), Complementary and Alternative Medicine for Cancer Care in India: Basic and Clinical Perspective, A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease, The ongoing nosologic dilemma with the metabolic syndrome, Therapeutic Activity and Safety of Vitamin K 2-7 in Muscle Cramps: An Interventional Case-Series, Persistence of Cytologic Abnormality After Treatment of Bacterial, Parasitic and Fungal Infections in Older Women with Low Grade Squamous Intraepithelial Lesion, Natural products drug discovery: Accelerating the clinical candidate development using reverse pharmacology approaches, Antioxidant activity of various extracts of leaves of Anacardium occidentale linn. Epidemiological studies from various countries co... Haridra (Curcuma longa Linn (Zingiberaceae family)) is a rhizomatous household spice and has been a widely used herb in India since ancient times. Footnotes. Turmeric bio-actives have shown potential anticancer activity in vitro, in vivo and in early clinical studies. The plant is reported to have anti-fungal, antioxidant and anti... Studies on the drying characteristics of Cashew leaves are scarce in the literature; particularly the traditional sun drying properties as well as oven drying properties of plants are not adequately investigated. A former Clinical Research Head of CIBA Geigy Research Centre, his name has been synonymous with the concept of the Golden Triangle for resurgence of Ayurveda and its reinterpretation in modern scientific terms. Drugs have been emerging serendipitously "from the bedside," without an organized approach. The patient was treated earlier to the referral empirically for pulmonary tuberculosis with no response to the treatment. © 2008-2021 ResearchGate GmbH. A scientific assessment of traditionally used antimalarial plants through reverse pharmacology is crucial for a fast track drug discovery. Animal experiments with urine in... Picroside II effects on β-oxidation genes: HepG2 cells were pretreated with picroside II and silibinin at a concentration of 10 μM, 2 hours prior to FFA (500 μM) loading for 20 hours followed by RT-PCR analysis of PPARα (A) and CPT1 (B). in malaria: An exploratory clinical study, Management of Parkinson's disease in Ayurveda: Medicinal plants and adjuvant measures, Reverse Pharmacology Effectuated by Studies of Ayurvedic Products for Arthritis, Simulation of an in vitro NAFLD model showed inhibition of lipid accumulation by Picroside II, Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract, Socioeconomics of obesity: A need for a national policy and a professional vigilance council, Integrative approached for health: Biomedical research Ayurveda and Yoga, A tribute to Prof. Ranjit Roy Chaudhury (1930-2015), Antilithic Activity of Citrus Medica Linn on Urinary Type Struvite Crystals, Antilithic Activity of Some Herbal Extracts on Urinary Type Struvite Crystals, Indian Breed Cow Milk - Powerhouse of Health, Dr. Ancel Benjamin Keys (1904-2004): Monsieur cholesterol and a driven interventionist, The influence of lifestyles on obesity: The impact of diet, sleep, exercise, and yoga, Yogacharya Dr. Bellur Krishnamachar Sundararaja Iyengar- "A Michelangelo of Yoga" (1918-2014), The theory and practice of yoga: Research findings and future vast potential for healthy lifestyles, Human microbiome: Impact on metabolic health, Clinical Perspective of Ayurceuticals: Challenges and Opportunities for Global Health and Well being, Clinical Perspective of Ayurceuticals: Challenges and Opportunities for Global Health and Wellness, Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer, Safety assessment of menaquinone-7 for use in human nutrition, Reverse Pharmacology-A Paradigm Shift for Drug Discovery and Development, Prakruti genomics and prameha-proclivity: relevance to metabolic syndrome, In vitro growth inhibition study of hydroxyapatite crystals in the presence of selected herbal extract solutions, Single dose metformin kinetics after co-administration of nisha-amalaki powder or mamejwa ghanavati, ayurvedic anti-diabetic formulations: A randomized crossover study in healthy volunteers, The formidable challenge of underweight, overweight and obese children in India, Chapter-45 Current Status of Indigenous Drugs and Alternative Medicine in the Management of Diabetes Mellitus, Metabolic management: The role of nutraceuticals, nutritionals and naturals, The effect of vitamin K2-7 in peripheral neuropathy due to Vitamin B12 deficiency and/or diabetes mellitus: A Preliminary Study, Comparative study of amrutbhallataka and glucosamine sulphate in osteoarthritis: Six months open label randomized controlled clinical trial. Obtainable on this site For many years the Archivist of the Hampshire Mills Group Tony Yoward, and his late wife Mary, researched and collected information about mills and millers. Due to our privacy policy, only current members can send messages to people on ResearchGate. The objective of the study is to evaluate the psychological and physiological effects of Shirodhara... Cashew is a tropical tree with immense commercial value and the use of its various parts in the confectionary, food, herbal and tanning industry has gained tremendous importance. Res. Dr Ashok Vaidya is an alumnus of GS Medical College and KEM Hospital, Mumbai. £12.99 + £2.00 p&p. His medical and research education was at Mumbai and at Yale. This is predated by Takenaka in 2001 (PMID 11589663). Advances in analytical chemistry and molecular biology have made it possible to unravel the p... Vitamin K occurs widely in foods and has been shown to have a beneficial effect on the cardiovascular system, as well as anticancer, anti-inflammatory, and antiosteoporosis properties. Ambulant OPD patients of OA knees (n = 112) were enrolled for 24 weeks. 1. The information oriented education system was now replaced with the investigation oriented education. Natural products of Ayurveda offer a vast potential for novel phy... Hydroxyapatite, is the most stable mineral found in body. Dr. Ashok D.B. The present study explored the effect of almond consumption on determinants of metabolic dysfunction - blood glucose, insulin, selected inflammatory markers and oxidant dama... Mitochondria in neurons, in addition to their primary role in bioenergetics, also contribute to specialized functions, including regulation of synaptic transmission, Ca ²⁺ homeostasis, neuronal excitability, and stress adaptation. A large percentage of Indian population has diabetes or is at risk of pre-diabetes. Around thirty Ayurvedic plants/drugs were screened for antidiabetic activity; four proved to be promising leads, and were later taken up in the CSIR NMITLI program. Hampshire Mills Group, 2012. J. Pharm. For this, a total of 52 T2DM patients were investigated, of which 38 received 500 mg - 1 g Indian Gentian thrice daily escalated over three months (Group 1). Supplementary Figure 1: Standardization of hydroalcoholic extract of Cassia aur... Safety pharmacology studies help in identifying preclinical adverse drug reactions. Dr. Ashok Vaidya with his wife Dr. Rama moved to Yale with the Merck International Fellowship. In addition to logical, sequential linear flow, Ayurveda also adopts multi-dimensional, one-to-many and many-to-many cause effect relations. In vitro Macrophage activation: A technique for evaluation of anti-inflammatory, immunomodulatory and anticancer activity of phytomolecules. (cashew), Isolation and quantitative analysis of a bioactive polyphenol - Catechin in Anacardium occidentale Linn. Join ResearchGate to find the people and research you need to help your work. Honorary Treasurer : Mr Glenn Barrett; FINANCIAL HISTORY. The sudden change to the environs of Yale were both invigorating and yet frightening. 2017; 42: 151-160. Material and Methods: An open labeled clinical study was conducted in 30 patients presenting with peripheral neuropathy and suffering from either megaloblastic anaem... AmrutBhallatak (ABFN02), a 'rasayana' drug from Ayurveda is indicated in degenerative diseases and arthritis. Almond consumption has shown benefits on cardio metabolic risk factors in adults. microns. He conducted the largest post-marketing surveillance trials. (Mini - review). See the complete profile on LinkedIn and discover ashok’s connections and jobs at similar companies. E-mail: editor.jomr@gmail.com. Rev. There is an urgent need of a paradigm shift in approaches to drug discovery. Distinguished Professor Clinical Pharmacology,Am Col Cl Ph S. Asia, Merck International Fellow in Clinical Pharmacology at Yale. Integrated Non-invasive Management of Cervical Low-Grade Squamous Intraepithelial Lesions Observed in Papanicolaou Smears with Antimicrobials Followed by Oral Curcuma Longa Extract, Post-COVID-19 rethinking for a synergic vision of health-care, Effect of Almond Consumption on Metabolic Risk Factors - Glucose, Hyperinsulinemia, Inflammatory Markers: A Randomized Controlled Trial in 16–25 year olds in Mumbai City, Enicostema axillare subsp. The present paper attempts to evaluate the physicochemical and preliminary phytochemical characteristics of Anacardium occidentale (Linn. A hypothesis was postulated three decades ago that beta casein the most abundant protein in milk contains a variant that is responsible for high incidence of type 1 diabetes mellitus(DM1) and cardiovascular disease... Cytokine research is currently at the forefront in cancer research. This chapter extensively reviews the current underst... Macrophage activation plays a significant role in homeostasis of organisms. Antioxidant activity of Leaves of Anacardium occidentale Linn. The first double-blind, placebo-controlled randomized clinical … Only verified researchers can join ResearchGate and send messages to other members. A Padma Shri award-winning medic, Dr. Ashok Vaid, Chairman, Medical and Hemato Oncology, Cancer Institute at Medanta The Medicity, has authored many publications, research papers, and abstracts. Ex-Prime Minister of Nepal & Convener of Naya Shakti Party, Nepal. However, the factors that influence mitochondrial biogenesis and function in neurons remain poorly elucidated. Dr. Vaidya has travelled extensively, as he has been a much-sought out speaker. Sorry, you need to be a researcher to join ResearchGate. We hope the forthcoming poster series on 'Syste... Ashwagandha (Withania somnifera) (WS), a "rasayana" drug, is recommended for balavardhan and mamsavardhan. All rights reserved. At Yale, he conducted trials with brocresine, p-CPA and L-dopa. Comprehensive view of concepts and logic is possible through this approach. The size of fine crystalline hydroxyapatite was found in order of Ashok Vaidya, Research Director, MRC- Kasturba Health Society Dr. Vaidya is from a lineage of Ayurveda and medicine; the heritage archives are a treasure trove for new leads from natural products. Reverse pharmacology for integrative research in Ayurveda and modern medicine. He was the Regional Medical Director for CIBA-GEIGY. ICMR’s Advanced Centre of Reverse Pharmacology in Traditional Medicine was awarded to Kasturba Health Society. understood well by many patients; therefore, their quest for complementary and alternative medicine (... As a major organ of intermediary metabolism, the liver is exposed to a variety of metabolic insults due to diseases and xenobiotics viz., insulin resistance (IR) drugs, toxins, microbial products, etc. Objectives View ashok vaidya’s profile on LinkedIn, the world’s largest professional community. There are innumerable references-Vedic and subsequent to the sacred significance of cow. Mobile Camera Photography for Quick Second Opinion for Pap Smear, Gallic acid protects RINm5F B-cells from glucolipotoxicity by its antiapoptotic and insulin-secretagogue actions, Roots of modern drugs in Reverse Pharmacology, An advocacy for Vaidya-Scientists in Ayurvedic research, Reverse pharmacology for natural drug discovery. Clinical and cytologic follow up of women with LSIL in Pap smears after treatment with oral Turmeric Oil. This approach generates evidence of safety and efficacy at different levels of biological organization , ranging from cell to community. Guide research in Drug discovery. OBJECTIVES . Later, at CIBA and KEM Hospital, he carried out Phase I, II and III trials on several new drug molecules. From the date of our conversion to a Charitable Incorporated Organisation, our accounts are visible on the website of the Charity Commission. This ‘Systems Ayurveda’ graphic notation describes schema of Ayurveda knowledge base. Reverse Pharmacology has led to new leads from plants for Parkinson’s disease, hepatitis, eczema, diabetes, cancer, arthritis,malaria etc. I thankfully acknowledge the continued guidance of Dr. Ashok Vaidya and creative assistance of Dr. Namyata Pathak in the preparation of this manuscript. a scholarly group of change agents, who are well vers... To determine whether Curcuma longa Linn extract, NBFR-03, can arrest low-grade squamous intraepithelial neoplasia (LSIL) a 12 week intervention study was performed. Dr. Vaidya has been honored with orations and awards. Radical-scavenging potential was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. ‘In vitro macrophage activation techniques provide us with a window to understand the mechanisms of inflammation and response of macrophages to the modulating int... Anti-cancer effects of medicinal plant products are mentioned in the ancient texts of Ayurved. Ashok D B Vaidya For millennia, cow has been central to Indian economy, life and culture. Moreover, FBS is cost-prohibitive for biomedical research. He has been a consultant and expert to W.H.O., CSIR, ICMR, DBT, AYUSH, and for the 11th and 12th five-year plans of India. Ashok Vaidya is on Facebook. Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. 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